货号：14-646

品牌：Merck Millipore

规格：10Ug

目录价：￥5200.00

市场价格：￥4420.00

会员价格：￥4160.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: TCPTP View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: Un-tagged, recombinant, human TCPTP, amino acids 1-341. View All» Key Applications: Phosphatase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported. View All» UniProt Summary: SIZE: 415 amino acids; 48528 Da SUBUNIT: Interacts with FAM82C/PTPIP51.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: PTPA isoform is probably the major PTP expressed in human tissues. PTPB isoform was found in T-cells and in placenta.SIMILARITY: SwissProt: P17706 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. & Contains 1 tyrosine-protein phosphatase domain. View All» Species: Human View All» Molecular Weight: 39.7kDa View All» Brand Family: Upstate View All» Source: Human TCPTP, expressed in E. coli cells. View All» Protein Target: TCPTP View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: Tyr phosphatase View All» Gene Symbol:

• PTPN2

• TCELLPTP

• TCPTP

• TC-PTP

• PTPT
  View All» Product Name: TCPTP View All» Quality Assurance: Routinely evaluated by dephosphorylation of DiFMUP. View All» UniProt Number: P17706 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number:
  • NM_002828.2

  • NM_080422.1

  • NM_080423.1
    View All» Purification Method: Glutathione agarose affinity chromatography View All»
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