货号：14-663

品牌：Merck Millipore

规格：10Ug

目录价：￥6586.00

市场价格：￥5598.10

会员价格：￥5268.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: CaM Kinase I, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: N-terminal GST-tagged, recombinant, human CaMK1, amino acids 2-end. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. View All» UniProt Summary: FUNCTION: SwissProt: Q14012 # Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes like transcriptional regulation, hormone production, translational regulation, regulation of actin filament organization and neurite outgrowth. Involved in calcium- dependent activation of the ERK pathway (By similarity). Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]- x(3)-[MVLIF]. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CTFR, MYL9, SYN1/synapsin I and SYNII/synapsin II (By similarity).SIZE: 370 amino acids; 41337 Da SUBUNIT: Monomer. Interacts with XPO1 (By similarity).SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Predominantly cytoplasmic (By similarity).TISSUE SPECIFICITY: Ubiquitous.DOMAIN:SwissProt: Q14012 The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate (By similarity).SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 68 kDa View All» Brand Family: Upstate View All» Source: Expressed in E. coli cells View All» Protein Target: CaMKI View All» Presentation: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 50% glycerol, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. View All» Storage Conditions: 6 months at -20°C View All» Target Sub-Family: CAMK View All» Gene Symbol:

• CAMK1

• CaMKI-alpha

• MGC120318

• CAMK1-PEN

• CAMKI

• CaM-KI

• CaMKI

• MGC120317
  View All» Product Name: CaM Kinase I, active View All» Quality Assurance: Routinely evaluated by phosphorylation of ZIPtide (#12-545). View All» UniProt Number: Q14012 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NM_003656.3 View All» Purification Method: Glutathione-agarose View All»
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