货号：14-669

品牌：Merck Millipore

规格：10Ug

目录价：￥6586.00

市场价格：￥5598.10

会员价格：￥5268.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: DYRK2, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: 6His-tagged, recombinant, full length human DYRK2 View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. View All» UniProt Summary: FUNCTION: SwissProt: Q92630 # Role in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.COFACTOR: Magnesium. & Manganese.SIZE: 601 amino acids; 66652 Da SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocates into the nucleus following DNA damage.TISSUE SPECIFICITY: Testis, after the onset of spermatogenesis.PTM: Phosphorylated on serine/threonine residues (By similarity).SIMILARITY: SwissProt: Q92630 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 63.5kDa View All» Brand Family: Upstate View All» Source: expressed by baculovirus in Sf21 cells View All» Protein Target: DYRK2 View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: CMGC View All» Gene Symbol:

• DYRK2

• FLJ21365

• FLJ21217
  View All» Product Name: DYRK2, active View All» Quality Assurance: routinely evaluated by phosphorylation of casein View All» UniProt Number: Q92630 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number:
  • NM_003583.2

  • NM_006482.1
    View All» Purification Method: Ni²⁺/NTA-agarose View All»
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