金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Tripeptidyl-Peptidase I/TPP1 Aliases: CLN2; LINCL; LPIC; TPP1 Entrez Gene IDs: 1200 (Human) Background: Tripeptidyl-peptidase I/TPP1 Tripeptidyl-peptidase I (TPP1), also known as CLN2, is a lysosomal serine protease detected in all tissues examined, with highest levels shown in heart and placenta. It is an aminopeptidase that cleaves tripeptides from the free N-terminus of polypeptides and may also have endopeptidase activity. Defects in TPP1 are the cause of classical late-infantile neuronal ceroid lipofusionosis, also known as ceroid lipofusionosis neuronal 2 (CLN2), a fatal childhood neurodegenerative disease characterized by progressive visual and mental decline, motor disturbance, epilepsy, and behavioral changes.