金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Histone H2AX Aliases: H2AFX Entrez Gene IDs: 3014 (Human) Background: Histone H2AX Histone H2AX is one of a number of core histone proteins. In the cellular response to genotoxic insults, ATM and related protein kinases phosphorylate the carboxyl-terminal tail of the H2AX protein (gamma-H2AX). gamma-H2AX marks the site of damage and provides a nucleation site for the formation of damage response and repair complexes. BRCA1 carboxyl terminal (BRCT) domain-containing proteins are recruited to gamma-H2AX to create a protein scaffold for further assembly of signaling complexes.