金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Insulysin/IDE Long Name: Insulin Degrading Enzyme Aliases: IDE; INSDEGM; Insulinase Entrez Gene IDs: 3416 (Human); 15925 (Mouse); 25700 (Rat) Background: Insulysin/IDE Insulysin, or insulin-degrading enzyme (IDE), is a zinc metallopeptidase of the inverzincin family. IDE is primarily located in the cytosol, but has been detected as a secreted enzyme and associated with the plasma membrane as well. The enzyme is expressed in many tissues, with the highest levels in liver, kidney, brain, and testis. IDE hydrolyzes a variety of regulatory peptides, including insulin, glucagon, atrial natriuretic factor, and transforming growth factor-alpha in vitro>. In addition, IDE has been shown to degrade the amyloid beta (A beta) peptide, which polymerizes into the plaques associated with Alzheimer's disease.