金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: CIS-1 Long Name: Cytokine Inducible SH2-containing Protein Aliases: CISH Entrez Gene IDs: 1154 (Human); 12700 (Mouse); 83681 (Rat) Background: CIS-1 CIS-1 (Cytokine-Inducible SH2-containing protein 1; also SOCS and Protein G18) is a SH2 domain-containing protein that belongs to the CIS/SOCS family of JAK-STAT modulators. CIS-1 stably interacts with tyrosine-phosphorylated cytokine receptors such as the EPOR and common beta chain. This interaction blocks STAT5 phosphorylation and subsequent downstream signaling.