金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: IRAK1 Long Name: Interleukin-1 Receptor-Associated Kinase 1 Aliases: Il1rak; Pelle; Plpk Entrez Gene IDs: 3654 (Human); 16179 (Mouse); 363520 (Rat) Background: IRAK Family IL-1 receptor-associated kinases (IRAKs) are serine/threonine kinases that help mediate signaling from Toll-like receptor (TLR) and IL-1 receptor family members. Four human IRAKs have been identified: IRAK1, IRAK2, IRAK-M, and IRAK4. All IRAKs are multidomain proteins, containing a conserved N-terminal death domain as well as a central kinase domain that is only active in IRAK1 and IRAK4. IRAK4 mutations have been described in patients with recurrent bacterial infections and poor inflammatory responses.