金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: ROCK2 Long Name: Rho-associated, Coiled-coil Containing Protein Kinase 2 Aliases: ROCK-II; ROKalpha Entrez Gene IDs: 9475 (Human); 19878 (Mouse); 25537 (Rat) Background: ROCK2 ROCK2/II (Rho-associated protein kinase 2; also Rho-kinase alpha) is a member of the AGC serine/threonine protein kinase family. ROCK2 is a downstream target of activated RhoA. Its activation results in myosin phosphorylation with subsequent muscle contraction. Human ROCK2 is 1388 amino acids (aa) in length, and appears to be present as a dimer. It contains a protein kinase domain (aa 92-354), a coiled-coil region (aa 429-1131) and a zinc-finger region (aa 1260-1315). Two isoforms show an alternate start site at M686, and a three aa substitution for the N-terminal 444 amino acids. Over aa 641-846, human ROCK2 shares 94% and 96% aa identity with mouse and canine ROCK2, respectively.