金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Kynureninase Aliases: L-kynurenine hydrolase; KYNU Entrez Gene IDs: 8942 (Human); 70789 (Mouse); 116682 (Rat) Background: Kynureninase Kynureninase (KYNU) catalyzes the hydrolytic cleavage of the amino acids L-kynurenine and L-3-hydroxykynurenine to give either anthranilic acid or 3-hydroxyanthranilic acid and alanine. KYNU degrades dietary tryptophan in the liver and is involved in the de novo biosynthesis of NAD⁺. In immune system cells, such as macrophages and microglia, KYNU catalyzes inflammatory quinolinic acid (QA) production, which may cause neuronal damage in AIDS-related dementia complex, Alzheimer's, stroke, epilepsy, and Huntington's disease.