金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Beclin 1/ATG6 Long Name: Beclin1, Autophagy-related Aliases: ATG6; BECN1; GT197; VPS30 Entrez Gene IDs: 8678 (Human); 56208 (Mouse); 114558 (Rat) Background: Beclin1 Beclin1 (Bcl-2 interacting coiled-coil protein; also know as ATG6) is a 60 kDa member of the Beclin family of proteins. It is part of a lipid-kinase complex that includes UVRAG and PI3 and induces autophagy; in the presence of Bcl-2, autophagy is repressed. Beclin1 is widely expressed but abundantly found in mammary epithelium, glia and neurons. Human Beclin1 is 450 amino acids (aa) in length and contains a Bcl-2 binding domain (aa 88-150), a nuclear export signal motif (aa 180-189), a coiled-coil region (aa 142-270), and an evolutionary conserved domain (aa 244-337). There is one potential alternate start site at Met88. Over aa 12-239, human Beclin1 is 98% aa identical to mouse Beclin1.