R&D Systems代理AF5387 Human PEDF R/PNPLA2 Affinity Purified Polyclonal Ab (100 UG)

2025-06-27

货号:AF5387

品牌:R&D Systems

规格:100ug

目录价:¥5040.00

市场价格:¥4032.00

会员价格:¥4032.00

  • 到货时间:3~4周

    金山科研平台,产品价格货期咨询微信:jinshanbio Molecule Information: PEDF R/PNPLA2 Long Name: Pigment Epithelium-derived Factor Receptor/Patatin-like Phospholipase Domain-containing Protein 2 Aliases: ATGL; Desnutrin; IPLA2-zeta; PNPLA2; TTS2 Entrez Gene IDs: 57104 (Human); 66853 (Mouse); 361676 (Rat) Background: PEDF R

    View PEDF R IHC images. PEDF R (Pigment epithelium derived factor receptor; also ATGL, PNPLA2 and desnutrin) is a 55 kDa member of the PNPLA family of proteins. It is expressed in adipocytes, hepatocytes, skeletal muscle and pigment epithelium. PEDF R specifically hydrolyses triglycerides, releasing long-chain fatty acids.

    Mouse PEDF R is described as being a 486 amino acid (aa) type II transmembrane (TM) protein. Its TM segment is stated to span aa 9 - 29. Alternatively, it may have a hydrophobic lipid-association domain between aa 267 - 295. It contains a palatin domain (aa 10 - 179) with a conserved GxSxG enzymatic motif. There are multiple splice forms. Two show alternate start sites at Met57 and Met232, while two others show a deletion of aa 163 - 196 and 253 - 308, respectively. Over aa 62 - 253, mouse PEDF R shares 98% and 93% aa identity with rat and human PEDF R, respectively.

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