金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: TRF-2 Long Name: Telomeric Repeat Binding Factor 2 Aliases: TERF2; TRBF2 Entrez Gene IDs: 7014 (Human); 21750 (Mouse); 361403 (Rat) Background: TRF-2 RF2 (telomeric repeat-binding factor 2; also telomeric DNA-binding protein) is a 55-60kDa, ubiquitously expressed nuclear protein that participates in telomere homeostasis. TRF2 binds as a dimer to TTAGGG repeats at ends of chromosomes (telomeres), where it blocks inappropriate activation of the ATM/p53 pathway. It also collaborates with TRF1 to promote normal telomere length. TRF2 has been found up regulated in several human cancers. Human TRF2 is 500 amino acids (aa) in length. It contains an N-terminal Arg-rich region (aa13-30), a dimerization domain (aa46-112), an NLS (aa329-333), and a DNA binding HTH myb-type domain (aa442-499). There is one potential alternate start site 42 aa upstream of the standard start site, and one splice form that shows a 13 aa substitution for aa239-500. Over aa78-238, human TRF2 shares 96% aa identity with mouse TRF2.