R&D Systems代理AF5769 Human MITF Affinity Purified Polyclonal Ab (100 UG)-试剂-金山科研平台

R&D Systems代理AF5769 Human MITF Affinity Purified Polyclonal Ab (100 UG)

2025-06-28

货号：AF5769

品牌：R&D Systems

规格：100ug

目录价：￥5040.00

市场价格：￥4032.00

会员价格：￥4032.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: MITF Long Name: Microphthalmia-associated Transcription Factor Aliases: bHLHe32; MI; WS2A Entrez Gene IDs: 4286 (Human); 17342 (Mouse); 25094 (Rat) Background: MITF

View MITF IHC images. MITF (Microphthalmia-associated transcription factor) is a member of the MiT/TFE family of molecules. Although it has a predicted MW of 58 kDa, it runs anomalously in SDS-PAGE at 57-66 kDa. MITF-A1 is found in melanocytes and RPEs where it regulates melanin synthesis via tyrosinase and TRP-1 gene expression. Human MITF-A1 is 526 amino acids (aa) in length. It contains a bHLH DNA binding region (aa 309-369) and a Leu-zipper domain (aa 374-395). There are three phosphorylation sites at Ser54/405/414, and two SUMOylation sites at Arg289/423. MITF-A1 acts as either a homodimer, or heterodimer with TFE3, TFEB or TFEC. Multiple splice variants exist, with each variant expressing one of two isoforms that are defined by the presence (#1), or absence (#2), of aa 294-299. One variant has a deletion of aa 139-194, a second has an 11 aa substitution for aa 1-118, and three others show variable substitutions over aa 1-35. Over aa 119-289, human MITF-A1 shares 96% aa identity with mouse MITF-A1.

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