R&D Systems代理AF5857 Human/Mouse NKX6.1 Affinity Purified Polyclonal Ab (100 UG)-试剂-金山科研平台

R&D Systems代理AF5857 Human/Mouse NKX6.1 Affinity Purified Polyclonal Ab (100 UG)

2025-06-27

货号：AF5857

品牌：R&D Systems

规格：100ug

目录价：￥5040.00

市场价格：￥4032.00

会员价格：￥4032.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: NKX6.1 Long Name: NK6 Homeobox 1 Aliases: NKX6-1; NKX6A Entrez Gene IDs: 4825 (Human); 18096 (Mouse); 65193 (Rat) Background: NKX6.1

View NKX6.1 IHC images. NKX6.1 (NK homeobox factor 6.1; also NKX6A) is a 39-46 kDa member of the homeodomain family of transcription factors. It is expressed in embryonic ventral neural tube where it drives neural progenitors to form motoneurons and V2-type interneurons. It is also expressed in both fetal and neonatal pancreas where it promotes a beta-cell phenotype. NKX6.1 exhibits both transcriptional gene repression (NKX6.2 and Dbx2) and activation (cyclin A2 and B1). When overexpressed, it induces beta-cell mitosis. Human NKX6.1 is 367 amino acids (aa) in length. It contains a repressor region composed of Pro and Ala (aa 136-173), a DNA binding homeobox (aa 236-295) and a Glu:Asp-rich transactivation domain (aa 305-337). Over aa 1-120, human NKX6.1 shares 96% aa identity with mouse NKX6.1.

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