R&D Systems代理AF6119 Human PTF1A Affinity Purified Polyclonal Ab (100 UG)-试剂-金山科研平台

R&D Systems代理AF6119 Human PTF1A Affinity Purified Polyclonal Ab (100 UG)

2025-06-27

货号：AF6119

品牌：R&D Systems

规格：100ug

目录价：￥5040.00

市场价格：￥4032.00

会员价格：￥4032.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: PTF1A Long Name: Pancreas-specific Transcription Factor 1a Aliases: PTF1-p48 Entrez Gene IDs: 256297 (Human); 19213 (Mouse); 117034 (Rat) Background: PTF1A

View PTF1A IHC images. PTF1A (Pancreas transcription factor 1a; also p48 and bHLHA29) is a cell specific member of the bHLH family of proteins. Although its predicted MW is 41 kDa, a high ratio of Pro, Leu and Ala increases its MW to 48 kDa in SDS-PAGE. PTF1A forms a trimeric transcription factor complex with a p75 subunit (HEB, E2 or E47) and a p64 subunit (usually RBP-L). Within this complex, unfortunately termed PTF1, p48/PTF1A binds to a DNA E-box while p64 binds to a TC-box. This regulates the gene transcription of about 20 enzymes synthesized by pancreatic acinar cells. Human PTF1A is 328 amino acids (aa) in length. It contains one basic DNA binding HLH motif (aa 150-175) and a dimerization interface (aa 178-219). Over aa 1-92, human PTF1A shares 88% aa identity with mouse PTF1A.

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