金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Tie-1 Long Name: Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains 1 Entrez Gene IDs: 7075 (Human); 21846 (Mouse) Background: Tie-1

Human Tie-1 cDNA encodes a 1138 amino acid (aa) residue precursor protein with a 24 residue putative signal peptide, a 735 residue extracellular domain and a 354 residue cytoplasmic domain. Ligands which bind and activate Tie-1 have not been identified. Based on gene targeting studies, the in vivo functions of Tie-1 have been shown to be related to endothelial cell differentiation and the maintenance of integrity of the endothelium.