R&D Systems代理AF6475 Mouse NKX3.1 Affinity Purified Polyclonal Ab (100 UG)-试剂-金山科研平台

R&D Systems代理AF6475 Mouse NKX3.1 Affinity Purified Polyclonal Ab (100 UG)

2025-06-27

货号：AF6475

品牌：R&D Systems

规格：100ug

目录价：￥5040.00

市场价格：￥4032.00

会员价格：￥4032.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: NKX3.1 Long Name: NK3 Homeobox 1 Aliases: BAPX2; NKX3-1; NKX3A Entrez Gene IDs: 4824 (Human); 18095 (Mouse); 305999 (Rat) Background: NKX3.1

View NKX3.1 IHC images. NKX3.1 (Homeobox protein NK-3 homolog A) is a 32-38 kDa member of the NK-3 homeobox family of transcription factors. It is expressed in testis and prostatic epithelium, and appears to be regulated by both testosterone and estrogen (but not progesterone). NKX3.1 apparently promotes prostate gland development, and acts as a tumor suppressor/transcriptional repressor by interacting with HDAC-1 and increasing p53 acetylation and half-life. Human NKX3.1 is 234 amino acids (aa) in length. It contains a DNA binding homeodomain (aa 124-183) and phosphorylation sites at Ser185 and Ser196 that regulate protein turnover. There are four splice variants that show changes N-terminal to the homeobox domain. Deletions of aa 8-56, 13-87, 15-83 and 40-83 are all reported. Over aa 1-123, human NKX3.1 shares 50% aa identity with mouse NKX3.1.

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