金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: TIGIT Long Name: T Cell Immunoreceptor with Ig and ITIM Domains Aliases: VSIG9; VSTM3; WUCAM Entrez Gene IDs: 201633 (Human); 100043314 (Mouse); 363784 (Rat) Background: TIGIT TIGIT (T cell Immunoreceptor with Ig and ITIM domains), also called Vstm3 (V-set and transmembrane domain-containing 3), Vsig9 (V-set and Ig domain-containing 9) and WUCAM (Washington University cell adhesion molecule) is a 30-34 kDa type I transmembrane protein that is a member of the CD28 family within the Ig superfamily of proteins. TIGIT is expressed on NK cells and subsets of activated, memory and regulatory T cells, and particularly on follicular helper T cells within secondary lymphoid organs. It binds to CD155/PVR/Necl-5 and Nectin-2/CD112/PVRL2 that appear on dendritic cells (DC) and endothelium. Through CD155 and Nectin-2, which also interact with DNAM-1/CD226 and CD96/Tactile, TIGIT is part of an interacting network of Ig superfamily members that may augment or oppose each other. Soluble TIGIT is able to compete with DNAM-1 for CD155 binding and attenuates T cell responses.