金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Ki-67/MKI67 Long Name: Antigen Identified by Monoclonal Antibody Ki-67 Aliases: KIA; MKI67; TSG126 Entrez Gene IDs: 4288 (Human); 17345 (Mouse); 291234 (Rat) Background: Ki-67/MKI67 Ki-67 (also MKI67and TSG126) is a 350-370 kDa nuclear protein that belongs to a molecular group comprised of mitotic chromosome-associated proteins. Ki-67 was originally recognized as an antigen associated with the monoclonal Ki-67 antibody raised against Hodgkin's lymphoma nuclear material. Ki-67 is contextually expressed, being potentially found in all cells that are not in the Go phase of the cell cycle. Thus, KI-67 qualifies as a cell proliferation marker. Functionally, Ki-67 is known to interact with 160 kDa Hklp2, a protein that promotes centrosome separation and spindle bipolarity. It also directly interacts with NIFK, and apparently binds to UBF, thus playing a role in rRNA synthesis.