金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: FLIP Long Name: FLICE Inhibitory Proteins Aliases: CASPER; CFLAR; FLAME-1; I-FLICE Entrez Gene IDs: 8837 (Human); 12633 (Mouse) Background: FLIP FLIP (Flice-like Inhibitory Protein), also known as I-FLICE, CASPER, and FLAME-1, is an apoptosis inhibitory protein with architecture similar to that of Caspases-8 and -10. Both of the FLIP isoforms, Long (L) and Short (S), contain two death effector domains (DED). FLIP(L) has a C-terminal Caspase-like protease domain which lacks both a catalytic active site and residues that form a substrate-binding pocket. FLIP(S) and FLIP(L) interact with the adaptor molecule FADD, and potently inhibit apoptosis initiated by Fas Ligand/TNF signaling pathways.