金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: PTEN Long Name: Phosphatase and Tensin Homolog Deleted on Chromosome 10 Aliases: MMAC1 Entrez Gene IDs: 5728 (Human); 19211 (Mouse); 50557 (Rat) Background: PTEN/MMAC1 The tumor suppressor gene PTEN (phosphatase and tensin homolog deleted on chromosome 10), also known as MMAC1 (mutated in multiple advanced cancers 1), encodes a phosphatase that contains the catalytic signature motif (HCXXGXXRS/T) found in all members of the protein tyrosine phosphatase family. In vitro, the recombinant PTEN has both lipid phosphatase and protein phosphatase activities. In vivo, the importance of PTEN catalytic activity in its tumor suppressor functions is underscored by the fact that the majority of PTEN missense mutations detected in tumor specimens target the phosphatase domain and cause a loss in PTEN phosphatase activity.