货号：14-679

品牌：Merck Millipore

规格：10Ug

目录价：￥5537.00

市场价格：￥4706.45

会员价格：￥4429.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: HIPK1, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: N-terminal 6His-tagged, recombinant, human HIPK1, amino acids 158-555. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. View All» UniProt Summary: FUNCTION: SwissProt: Q86Z02 # May play a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. May be involved in malignant squamous cell tumor formation.SIZE: 1210 amino acids; 130843 Da SUBUNIT: Interacts with Nkx1-2 and Nkx2-5 (By similarity). Interacts with DAXX and TP53.SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Note=Predominantly nuclear.TISSUE SPECIFICITY: Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines.PTM: Autophosphorylated. Phosphorylated and activated by JNK1.SIMILARITY: SwissProt: Q86Z02 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 49.6kDa View All» Brand Family: Upstate View All» Source: HIPK1 expressed by baculovirus in Sf21 cells. View All» Protein Target: HIPK1 View All» Storage Conditions: 6 months at -70°C from date of shipment View All» Target Sub-Family: CMGC View All» Gene Symbol:

• HIPK1

• MGC33446

• KIAA0630

• Nbak2

• MGC26642

• MGC33548

• Myak
  View All» Product Name: HIPK1, active View All» Quality Assurance: routinely evaluated by phosphorylation of MBP (13-104). View All» UniProt Number: Q86Z02 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number:
  • NM_152696.3

  • NM_181358.1

  • NM_198268.1

  • NM_198269.1
    View All» Purification Method: Ni²⁺/NTA-agarose View All»
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