货号：14-680

品牌：Merck Millipore

规格：

目录价：￥3735.00

市场价格：￥3174.75

会员价格：￥2988.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: HIPK3, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: N-terminal 6His-tagged, recombinant, human HIPK3, amino acids 161-562 View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» UniProt Summary: FUNCTION: SwissProt: Q9H422 # Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors.SIZE: 1215 amino acids; 133743 Da SUBUNIT: Interacts with Nkx1-2. Interacts with FAS and DAXX. Probably part of a complex consisting of HIPK3, FAS and FADD. Interacts with and stabilizes ligand-bound androgen receptor (AR) (By similarity). Interacts with UBL1/SUMO-1.SUBCELLULAR LOCATION: Cytoplasm. Nucleus.TISSUE SPECIFICITY: Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung.PTM: Autophosphorylated, but autophosphorylation is not required for catalytic activity (By similarity). & May be sumoylated (By similarity).SIMILARITY: SwissProt: Q9H422 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 49.7kDa View All» Brand Family: Upstate View All» Source: expressed by baculovirus in Sf21 cells View All» Protein Target: HIPK3 View All» Storage Conditions: Stable 6 months at -70°C from date of shipment View All» Target Sub-Family: CMGC View All» Gene Symbol:

• HIPK3

• FIST

• DYRK6

• ANPK

• PKY

• YAK1

• FIST3
  View All» Product Name: HIPK3, active View All» Quality Assurance: routinely evaluated by phosphorylation of MBP (Catalog # 13-104) View All» UniProt Number: Q9H422 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme View All» Entrez Gene Number:
  • NM_001048200.1

  • NM_005734.3
    View All» Purification Method: Ni²⁺/NTA-agarose View All»
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