货号：14-681M

品牌：Merck Millipore

规格：1ea

目录价：￥42566.00

市场价格：￥36181.10

会员价格：￥34052.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Flt-4, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: N-terminal GST-tagged, recombinant human Flt4, amino acids 800-end View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» UniProt Summary: FUNCTION: SwissProt: P35916 # Receptor for VEGFC. Has a tyrosine-protein kinase activity.SIZE: 1298 amino acids; 145599 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Placenta, lung, heart, and kidney, does not seem to be expressed in pancreas and brain.DISEASE: SwissProt: P35916 # Defects in FLT4 are the cause of hereditary lymphedema I [MIM:153100]; also known as Nonne-Milroy lymphedema or Milroy disease. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment. Hereditary lymphedema I shows autosomal dominant inheritance and is characterized by onset usually at birth. & Defects in FLT4 are found in juvenile hemangioma. Juvenile hemangiomas are the most common tumors of infancy, occurring as many as 10/% of all births. These benign vascular lesions enlarge rapidly during the first year of life by hyperplasia of endothelial cells and attendant pericytes, and then spontaneously involute over a period of years, leaving loose fibrofatty tissue.SIMILARITY: SwissProt: P35916 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 7 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 90.9kDa View All» Brand Family: Upstate View All» Source: expressed by baculovirus in Sf21 cells View All» Protein Target: Flt4 View All» Storage Conditions: 6 months at -70°C from date of shipment View All» Target Sub-Family: TK View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• FLT4

• PCL

• VEGFR-3

• FLT41

• VEGFR3
  View All» Product Name: Flt-4, active View All» Quality Assurance: routinely evaluated by phosphorylation of 500μM JAK3tide (Catalog # 12-547) View All» UniProt Number: P35916 View All» Packaging: Also available in 10 μg size (cat#14-681) and in bulk (cat# 14-681-K). View All» Entrez Gene Number:
  • NM_002020.3

  • NM_182925.3
    View All» Purification Method: Glutathione-agarose View All»
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