货号：14-684

品牌：Merck Millipore

规格：10Ug

目录价：￥6586.00

市场价格：￥5598.10

会员价格：￥5268.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: IRAK1, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: N-terminal 6His-tagged, recombinant, human IRAK1 amino acids 194-end. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P51617 # Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1.COFACTOR: Magnesium.SIZE: 712 amino acids; 76537 Da SUBUNIT: IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Interacts with IL1RL1.TISSUE SPECIFICITY: Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2.PTM: Autophosphorylated or is transphosphorylated by IRAK4 following recruitment to the IL-1RI. In the case of isoform 1, this is linked to ubiquitination and degradation.SIMILARITY: SwissProt: P51617 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 59.7kDa View All» Brand Family: Upstate View All» Source: Human IRAK1 expressed by baculovirus in Sf21 cells. View All» Protein Target: IRAK1 View All» Storage Conditions: 6 months at -70°C from date of shipment View All» Target Sub-Family: TKL View All» Gene Symbol:

• IRAK1

• IRAK

• IRAK-1

• pelle
  View All» Product Name: IRAK1, active View All» Quality Assurance: routinely evaluated by phosphorylation of MBP (13-104). View All» UniProt Number: P51617 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 250 µg size --call for pricing and availability and reference catalog number 14-684M when ordering the 250 µg size. View All» Entrez Gene Number:
  • NM_001025242.1

  • NM_001025243.1

  • NM_001569.3
    View All» Purification Method: Ni²⁺/NTA-agarose View All»
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    © Merck Millipore代理14-684 IRAK1 Protein, active, 10 µg;IRAK1蛋白，活性，10 µgstore at -80℃，产品报价联系微信jinshanbio