货号：14-685M

品牌：Merck Millipore

规格：250Ug

目录价：￥41939.00

市场价格：￥35648.15

会员价格：￥33551.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Cdk9/Cyclin T1, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: C-terminal 6His-tagged, fulllength recombinant, human cdk9 co-expressed with untagged, full-length human cyclin T1 View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. View All» UniProt Summary: FUNCTION: SwissProt: P50750 # Member of the cyclin-dependent kinase pair (CDK9/cyclin- T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II), SUPT5H and RDBP. The CDK9/cyclin-K complex has also a kinase activity toward CTD of RNAP II and can substitute for P-TEFb in vitro.SIZE: 372 amino acids; 42778 Da SUBUNIT: Associates with CCNT1/cyclin-T1 to form P-TEFb. P-TEFb forms a complex with AFF4/AF5Q31. Also associates with CCNK/cyclin-K. Component of a complex which is at least composed of HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II, SUPT5H, and NCL/nucleolin. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs.SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Ubiquitous.SIMILARITY: SwissProt: P50750 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 44kDa (cdk9) and 80.79kDa (cyclinT1) View All» Brand Family: Upstate View All» Source: expressed by baculovirus in Sf21 insect cells View All» Protein Target: CDK9/cyclin T1 View All» Storage Conditions: stable for 6 months at -70°C from date of shipment View All» Target Sub-Family: CMGC View All» Gene Symbol:

• CDK9

• C-2k

• PITALRE

• TAK

• CDC2L4

• C-2K
  View All» Product Name: Cdk9/Cyclin T1, active View All» Quality Assurance: routinely evaluated by phosphorylation of PDKtide (Catalog# 12-401) View All» UniProt Number: P50750 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 10 μg size (cat#14-685) and in bulk (cat# 14-685-K). View All» Entrez Gene Number: NM_001261.2 View All» Purification Method: Ni²⁺/NTA-agarose View All»
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