货号：14-691

品牌：Merck Millipore

规格：

目录价：￥3677.00

市场价格：￥3125.45

会员价格：￥2941.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: MRCKα, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: C-terminal 6His-tagged, recombinant, human MRCKα, amino acids 1-473. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. View All» UniProt Summary: FUNCTION: SwissProt: Q5VT25 # May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation.COFACTOR: Magnesium.SIZE: 1732 amino acids; 197307 Da SUBUNIT: Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42.SUBCELLULAR LOCATION: Cytoplasm (By similarity). Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity).TISSUE SPECIFICITY: Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver.SIMILARITY: SwissProt: Q5VT25 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 CNH domain. & Contains 1 CRIB domain. & Contains 1 PH domain. & Contains 1 phorbol-ester/DAG-type zinc finger. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 55.3kDa View All» Brand Family: Upstate View All» Source: MRCKα, amino acids 1-473, expressed by baculovirus in Sf21 cells View All» Protein Target: MRCKα View All» Storage Conditions: 6 months at -70°C from date of shipment View All» Target Sub-Family: AGC View All» Gene Symbol:

• CDC42BPA

• DKFZp686L1738

• PK428

• DKFZp686P1738

• KIAA0451

• FLJ23347

• MRCK

• MRCKA
  View All» Product Name: MRCKα, active View All» Quality Assurance: routinely evaluated by phosphorylation of S6 Kinase/Rsk2 Substrate Peptide 2 (KKRNRTLTV) View All» UniProt Number: Q5VT25 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number:
  • NM_003607.3

  • NM_014826.4
    View All» Purification Method: Ni²⁺/NTA-agarose View All»
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