货号：14-696

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: MAP Kinase 2/Erk 2 (K52R), inactive View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 100 µg View All» Product Overview: N-terminal 6His-tagged recombinant full-length mouse MAP Kinase 2/Erk2 containing a K52R mutation View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P63085 #Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The the MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis.COFACTOR: Magnesium (By similarity).DOMAIN: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain. View All» Species: E. coli View All» Molecular Weight: 45kDa View All» Brand Family: Upstate View All» Source: expressed in E. coli View All» Protein Target: MAPK2 View All» Storage Conditions: 1 year at -20°C from date of shipment View All» Target Sub-Family: CMGC View All» Gene Symbol:

• MAPK1

• p40

• PRKM2

• MAPK2

• PRKM1

• p42-MAPK

• p38

• ERK

• ERK-2

• ERT1

• P54MAPK

• P41MAPK

• ERK2
  View All» Product Name: MAP Kinase 2/Erk 2 (K52R), inactive View All» Quality Assurance: MAP Kinase 2/Erk2 (K52R), inactive was phosphorylated by MEK1 (Catalog # 14-429), and the results confirmed by Western blotting using Anti-phospho-MAP Kinase 1/2 (Erk1/2) (Catalog #07-467). The absence of kinase activity of the phosphorylated MAP Kinase 2/Erk2 (K52R) was tested using MBP (Catalog # 13-110) as a substrate. View All» UniProt Number: P63085 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NM_011949.3 View All» Purification Method: Ni²⁺/NTA-agarose View All»
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