货号：14-728

品牌：Merck Millipore

规格：1EA

目录价：￥5959.62

市场价格：￥5065.68

会员价格：￥4767.70

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Mer, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: N-terminal GST-tagged, recombinant, human Mer, amino acids 557-882 View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). View All» UniProt Summary: SIZE: 999 amino acids; 110249 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).TISSUE SPECIFICITY: Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines.DISEASE: SwissProt: Q12866 # Defects in MERTK are a cause of retinitis pigmentosa (RP) [MIM:268000]. RP that leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.SIMILARITY: SwissProt: Q12866 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. & Contains 2 fibronectin type-III domains. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 64.4kDa View All» Brand Family: Upstate View All» Source: expressed by baculovirus in Sf21 cells View All» Protein Target: Mer View All» Storage Conditions: 6 months at -70°C from date of shipment View All» Target Sub-Family: TK View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• MERTK

• MGC133349

• c-mer

• mer

• MER

• MER-PEN
  View All» Product Name: Mer, active View All» Quality Assurance: routinely evaluated by phosphorylation of 250μM substrate peptide (GGMEDI View All» UniProt Number: Q12866 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NM_006343.2 View All» Purification Method: Glutathione-agarose View All»
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