金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Coagulation Factor II/Thrombin Aliases: F2; Thrombin Entrez Gene IDs: 2147 (Human) Background: Coagulation Factor II/Thrombin Coagulation Factor II/thrombin is an essential component of the coagulation cascade in which it converts fibrinogen to fibrin, activates coagulation factors V, VII, VIII, XIII and forms complexes with protein C and thrombomodulin. It also activates platelets and regulates the behavior of additional cells through protease-activated receptors (PARs). A plasma serine protease, thrombin is synthesized as a 622 amino acid precursor with a 24 amino acid signal peptide and a 19 residue pro peptide. The mature chain can be further processed into several forms including those designated as alpha-, beta- and gamma-thrombin.