货号：14-744M

品牌：Merck Millipore

规格：1ea

目录价：￥42566.00

市场价格：￥36181.10

会员价格：￥34052.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Haspin, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: N-terminal 6His-tagged, recombinant, human Haspin, amino acids 471-end, expressed by baculovirus in Sf21 insect cells. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» UniProt Summary: FUNCTION: SwissProt: Q8TF76 # Required for normal alignment of chromosomes at metaphase. Phosphorylates histone H3 'Thr-3' during mitosis.COFACTOR: Magnesium.SIZE: 798 amino acids; 88460 Da SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines.PTM: Autophosphorylated on both serine and threonine residues (By similarity). Phosphorylated during mitosis. Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY: SwissProt: Q8TF76 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 41.1 kDa View All» Brand Family: Upstate View All» Source: Recombinant enzyme expressed in Sf21 cells View All» Protein Target: haspin View All» Presentation: 10 μg of enzyme in 6.3 μL of 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij 35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. View All» Storage Conditions: Stable for 6 months at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap. Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70°C. View All» Target Sub-Family: Misc View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• GSG2

• H-Haspin

• haspin
  View All» Product Name: Haspin, active View All» Quality Assurance: Routinely evaluated by phosphorylation of 500 μM RARTLSFAEPG. Purity was assessed by SDS-PAGE and Coomassie blue staining using 3μg of Haspin. View All» UniProt Number: Q8TF76 View All» Specific Activity: 2237U/mg, where one unit of Haspin activity is defined as 1 nmol phosphate incorporated into 500 μM RARTLSFAEPG per minute at 30°C with a final ATP concentration of 100 μM. View All» Packaging: Also available in 10 μg size (cat#14-744) and in bulk (cat# 14-744-K). View All» Entrez Gene Number: NM_031965.2 View All» Purification Method: Purified using Ni²⁺/NTA agarose. Purity 83% by SDS-PAGE and Coomassie blue staining. View All»
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