货号：14-772

品牌：Merck Millipore

规格：

目录价：￥4733.00

市场价格：￥4023.05

会员价格：￥3786.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: ULK2, active View All» Qty/Pk: 10 µg View All» Product Overview: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator ofmammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: maygovern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Species: Human View All» Molecular Weight: 62 kDa View All» Quality Assurance: Routinely evaluated by phosphorylation of casein View All» Brand Family: Upstate View All» Source: N-terminal GST and C-terminal 6His-tagged, recombinant, human, ULK2, amino acids 1–306. Expressed by baculovirus in Sf21 insect cells View All» Presentation: Protein in 50mM Tris/HCl pH7.2, 300mM NaCl, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1mM EGTA, 0.1% 2-mercaptoethanol, 0.03% Brij-35. Frozen solution. View All» UniProt Number: Q8IYT83 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Storage Conditions: Store at -70°C View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Packaging: Also available in 250μg size as catalog # 14-772M and in bulk as catalog # 14-772-K. View All» Gene Symbol: ULK2 View All» Product Name: ULK2, active View All» Entrez Gene Number: NM_014683 View All» Purification Method: Purified using glutathione agarose. View All»