货号：14-782

品牌：Merck Millipore

规格：10Ug

目录价：￥5200.00

市场价格：￥4420.00

会员价格：￥4160.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PI 3-Kinase (p110α(E542K)/p85α), Human View All» Qty/Pk: 10 μg View All» Product Overview: Complex of N-terminal 6His-tagged, recombinant, full-length human p110α containing the mutation E542K and untagged, recombinant, full-length human p85α. View All» Background Information: The E542K substitution is a somatic mutation in p110α that has been associated with tumours of the colon and brain. Combined in vitro and in vivo studies have shown that this mutation confers higher lipid kinase activity than wild type, and is able to induce oncogenic transformation. View All» Key Applications: Kinase Assay View All» Entrez Gene Summary: Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. View All» UniProt Summary: FUNCTION: SwissProt: P42336 # Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.SIZE: 1068 amino acids; 124284 Da SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Binds to IRS1 in nuclear extracts. Interacts with RUFY3 (By similarity).DISEASE: SwissProt: P42336 # Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500]. & Defects in PIK3CA are associated with breast cancer [MIM:114480]. & Defects in PIK3CA are associated with epithelial ovarian cancer (EOC) [MIM:604370].SIMILARITY: SwissProt: P42336 ## Belongs to the PI3/PI4-kinase family. & Contains 1 C2 domain. & Contains 1 PI3K/PI4K domain. View All» Species: Human View All» Molecular Weight: p110α (E542K) MW = 125.3kDa, p85α MW = 83.7kDa. View All» Source: Coexpressed by baculovirus in Sf21 insect cells. View All» Protein Target: PI3Kα/p85α View All» Storage Conditions: Store at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap. Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70°C. View All» Target Sub-Family: PI3K/PI4K View All» Gene Symbol:

• PIK3CA

• PI3K

• MGC142161

• p110-alpha

• MGC142163
  View All» Product Name: PI3 Kinase (p110α (E542K)/p85α) View All» UniProt Number: P42336 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 250 μg size --call for pricing and availability and reference catalog number 14-782M when ordering the 250 μg size. View All» Entrez Gene Number: NM_006218.2 View All» Purification Method: Ni²⁺/NTA-agarose View All»
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  © Merck Millipore代理14-782 PI 3-Kinase (p110α(E542K)/p85α), Human, 10 µg;PI 3-激酶（p110α(E542K)/p85α），人，10 µgstore at -80℃，产品报价联系微信jinshanbio