货号：14-784

品牌：Merck Millipore

规格：

目录价：￥12063.00

市场价格：￥10253.55

会员价格：￥9650.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: mTOR and FKBP12 View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 1 kit View All» Product Overview: This product includes 10 µg of active mTOR (1362-end) and 1 mg of FKBP12. View All» Background Information: FKBP12: N-terminal 6His-tagged recombinant, full length, human FKBP12, expressed in E.coli. mTOR (1362-end), active: N-terminal FLAG™-tagged, recombinant, human mTOR, amino acids 1362-end, expressed by baculovirus in Sf21 insect cells. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The CDT6 gene is located in an intron of this gene. View All» UniProt Summary: FUNCTION: SwissProt: P42345 # Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.SIZE: 2549 amino acids; 288892 Da SUBUNIT: Interacts with the FKBP12-rapamycin complex. Binds UBQLN1. Forms part of the mammalian target of rapamycin 2 complex (TORC2) comprised of FRAP1, GBL, PRR5, RICTOR and SIN. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to PRR5 and RICTOR within the TORC2 complex.TISSUE SPECIFICITY: Expressed in numerous tissues, with highest levels in testis.SIMILARITY: SwissProt: P42345 ## Belongs to the PI3/PI4-kinase family. & Contains 1 FAT domain. & Contains 1 FATC domain. & Contains 7 HEAT repeats. & Contains 1 PI3K/PI4K domain. View All» Species: Human View All» Brand Family: Upstate View All» Protein Target: mTOR (FRAP1) View All» Presentation: mTOR Enzyme in 10mM HEPES, 50mM NaCl, 50mM β-glycerophosphate, 0.25 mM sodium orthovanadate, 10 mM NaF, 300 μg/ml FLAG™ peptide, 20% v/v glycerol.FKBP12in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij 35, 270mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. View All» Storage Conditions: Store -70°C View All» Target Sub-Family: Lipid/Atypical View All» Gene Symbol:

• FRAP1

• RAPT1

• MTOR

• FRAP

• mTOR

• FLJ44809

• FRAP2

• RAFT1
  View All» Product Name: mTOR and FKBP12 View All» Components:
  • mTOR (1362-end), active (Cat.# 14-770)

  • FKBP12
    View All» UniProt Number: P42345 View All» Entrez Gene Number: NM_004958.2 View All»
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