货号：14-786

品牌：Merck Millipore

规格：

目录价：￥4497.00

市场价格：￥3822.45

会员价格：￥3597.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PI3 Kinase (p110α/p65α) Murine View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 μg View All» Product Overview: Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α and untagged, recombinant, full length mouse p65α. View All» Background Information: p65α is an oncogenic mutant form of p85α(residues 1-571) which leads to increased PI3K activity. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. View All» UniProt Summary: FUNCTION: SwissProt: P42336 # Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.SIZE: 1068 amino acids; 124284 Da SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Binds to IRS1 in nuclear extracts. Interacts with RUFY3 (By similarity).DISEASE: SwissProt: P42336 # Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500]. & Defects in PIK3CA are associated with breast cancer [MIM:114480]. & Defects in PIK3CA are associated with epithelial ovarian cancer (EOC) [MIM:604370].SIMILARITY: SwissProt: P42336 ## Belongs to the PI3/PI4-kinase family. & Contains 1 C2 domain. & Contains 1 PI3K/PI4K domain. View All» Species: Mouse View All» Molecular Weight: p110α MW = 129kDa, p65α MW = 65.9kDa View All» Brand Family: Upstate View All» Source: Coexpressed by baculovirus in Sf21 insect cells View All» Protein Target: PI3Kα/p65α View All» Storage Conditions: Store at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap View All» Target Sub-Family: PI3K/PI4K View All» Gene Symbol:

• PIK3CA

• PI3K

• MGC142161

• p110-alpha

• MGC142163
  View All» Product Name: PI3 Kinase (p110α/p65α) Murine View All» UniProt Number: P42336 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 250μg size --call for pricing and availability and reference catalog number 14-786M when ordering the 250μg size. View All» Entrez Gene Number: NM_006218.2 View All» Purification Method: Ni²⁺/NTA-agarose View All»
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