货号：14-791

品牌：Merck Millipore

规格：

目录价：￥4497.00

市场价格：￥3822.45

会员价格：￥3597.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PI 3-Kinase (p110α(E542K)/p85α) murine View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 μg View All» Product Overview: Complex of N-terminal 6His-tagged recombinant murine p110α full length, containing the mutation E542K, and untagged, recombinant, murine p85α full length. View All» Background Information: The E542K substitution is a somatic mutation in p110α that has been associated with tumours of the colon and brain. Combined in vitro and in vivo studies have shown that this mutation confers higher lipid kinase activity than wild type, and is able to induce oncogenic transformation. (Kang S. et al., PNAS, (2005);102: 802-807 and Zhao J.J. et al., PNAS, (2005);102:18443-18448). View All» Species: Mouse View All» Molecular Weight: p110α(E542K) MW = 129 kDa, p85α MW = 84 kDa. View All» Brand Family: Upstate View All» Source: Co-expressed by baculovirus in Sf21 insect cells. View All» Protein Target: PI3Kα/p85α View All» Presentation: 50 mM Tris/HCl pH7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 0.2 mM PMSF, 1 mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution. View All» Storage Conditions: Store at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap. View All» Target Sub-Family: PI3K/PI4K View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• PIK3CA

• PI3K

• PK3CA
  View All» Product Name: PI 3-Kinase (p110α(E542K)/p85α) murine View All» UniProt Number:
  • P42336 / P27986

  • P42337 / P26450 (mouse)
    View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 250μg size --call for pricing and availability and reference catalog number 14-791M when ordering the 250μg size. View All» Entrez Gene Number: BC089038 View All» Purification Method: Ni²⁺/NTA-agarose View All»
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