货号：14-792M

品牌：Merck Millipore

规格：

目录价：￥30125.00

市场价格：￥25606.25

会员价格：￥24100.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PI 3-Kinase (p110α(H1047R)/p85α) View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: Complex of N-terminal 6His-tagged recombinant human p110α full length, containing the mutation H1047R, and untagged, recombinant, human p85α full length. View All» Background Information: The H1047R substitution is a somatic mutation in p110α that has been associated with tumours of the colon, stomach, breast and brain. Combined in vitro and in vivo studies have shown that this mutation confers higher lipid kinase activity than wild type, and is able to induce oncogenic transformation. (Samuels Y. et al., Science, (2004); 304: 554; Kang S. et al., PNAS, (2005);102: 802-807 and Zhao J.J. et al., PNAS, (2005);102:18443-18448). View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Species: Human View All» Molecular Weight: p110α(H1047R) MW = 125 kDa, p85α MW = 84 kDa. View All» Brand Family: Upstate View All» Source: Co-expressed by baculovirus in Sf21 insect cells. View All» Protein Target: PI3Kα/p85α View All» Presentation: 50 mM Tris/HCl pH8.0, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 0.2 mM PMSF, 1 mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution. View All» Storage Conditions: Store at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap. View All» Target Sub-Family: PI3K/PI4K View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• PIK3CA

• PI3K

• PK3CA
  View All» Product Name: PI 3-Kinase (p110α(H1047R)/p85α) View All» UniProt Number:
  • P42336 / P27986

  • P42337 / P26450 (mouse)
    View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 10 μg size (cat#14-792) and in bulk (cat# 14-792-K). View All» Entrez Gene Number: U79143 View All» Purification Method: Ni²⁺/NTA-agarose View All»
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