货号：14-808

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: UbcH3 Conjugating Enzyme View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 100 µg View All» Product Overview: UbcH3 is a class II enzyme, homologous to Cdc34 from Saccharomyces cerevisiae, and is important in the control of cell cycle and DNA replication. UbcH3/Cdc34 in association with different E3 complexes, including SCF, has been shown to target many different substrates for ubiquitination and degradation during cell division, signal transduction, and development. UbcH3 has been demonstrated to self-associate through a domain in the C-terminus, and is phosphorylated and ubiquitinylated in vivo. This protein is useful for in vitro ubiquitinylation reactions. Typical enzyme concentration to support conjugation in vitro is 100nM to 1μM depending upon conditions. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. View All» UniProt Summary: FUNCTION: SwissProt: P49427 # Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in degradation of katenin.SIZE: 236 amino acids; 26737 Da SUBUNIT: Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. When phosphorylated, interacts with beta-TrCP (BTRC).SIMILARITY: SwissProt: P49427 ## Belongs to the ubiquitin-conjugating enzyme family. View All» Species: Human View All» Molecular Weight: 32 kDa View All» Brand Family: Upstate View All» Source: Recombinant human UbcH3 Conjugating Enzyme expressed in E. coli. View All» Storage Conditions: Stable for 1 year at -80°C from date of shipment. Avoid multiple freeze/thaw cycles. After initial defrost, aliquot into individual tubes and refreeze at -80°C. View All» Gene Symbol:

• CDC34

• UBE2R1

• E2-CDC34

• UBC3
  View All» Product Name: UbcH3 Conjugating Enzyme View All» UniProt Number: P49427 View All» Entrez Gene Number: NM_004359.1 View All» Purity: >95% by SDS-PAGE View All»
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