货号：14-835

品牌：Merck Millipore

规格：10Ug

目录价：￥6586.00

市场价格：￥5598.10

会员价格：￥5268.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Aurora B, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 ug View All» Product Overview: His-tagged, recombinant, human Aurora B, full length and N-terminal GST-tagged, recombinant, human INCENP, amino acids 821-end View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al., 2004 [PubMed 14767480]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: Q96GD4 # May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis.COFACTOR: Magnesium.SIZE: 344 amino acids; 39280 Da SUBUNIT: Interacts with TACC1. Associates with RACGAP1 during M phase. Component of the CPC at least composed of BIRC5/survivin CDCA8/borealin, INCENP and AURKB/Aurora-B. Interacts with CDCA1 and KNTC2. Interacts with EVI5.SUBCELLULAR LOCATION: Nucleus. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalized with gamma tubulin in the mid- body.TISSUE SPECIFICITY: High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase.DISEASE:SwissProt: Q96GD4 # Disruptive regulation of expression is a possibile mechanism of the perturbation of chromosomal integrity in cancer cells through its dominant-negative effect on cytokinesis.SIMILARITY: SwissProt: Q96GD4 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. & Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: Aurora B = 40 kDaINCENP = 38 kDa View All» Brand Family: Upstate View All» Source: human Aurora B, human INCENP co-expressed by baculovirus in Sf21 insect cells. View All» Protein Target: Aurora-B View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: AGC View All» Gene Symbol:

• AIM-1

• STK12

• Aik2

• IPL1

• Aurora-B

• ARK2

• aurora-B

• AIK2

• AIM1

• AurB

• STK5

• aurora-1

• STK-1

• AURKB
  View All» Product Name: Aurora B, active View All» UniProt Number: Q96GD4 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NM_004217 View All» Purification Method: Glutathione-agarose View All»
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