货号：14-844M

品牌：Merck Millipore

规格：

目录价：￥35565.00

市场价格：￥30230.25

会员价格：￥28452.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PIP5K1α, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: N-terminal 6His-tagged, recombinant human PIP5K1α, full length. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2 (By similarity) View All» UniProt Summary: FUNCTION: Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2 CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.SUBUNIT STRUCTURE: Interacts with ARF1, RAC1, PLD1, PLD2 and JUBSUBCELLULAR LOCATION: Cell membrane. Endomembrane system. Golgi apparatus › Golgi stack. Note: Associated with the plasma membrane and with internal membranes. Associated with Golgi stacks. Detected on RAC1-induced plasma membrane ruffles, and on membrane ruffles induced by platelet-derived growth factor.TISSUE SPECIFICITY: Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in brain, lung and liver.SIMILARITY: Contains 1 PIPK domain. View All» Species: Human View All» Molecular Weight: 60kDa View All» Brand Family: Upstate View All» Source: Expressed by baculovirus in Sf21 insect cells View All» Protein Target: PIP5K1α View All» Presentation: 10µg of enzyme in 50mM Tris/HCl pH8.0, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 0.2mM PMSF, 1mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution. View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: PIPK View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol: PIP5K1A View All» Product Name: PIP5K1α, active View All» Quality Assurance: Routinely evaluated in the PIProfiler. View All» UniProt Number: Q99755 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 10 μg size (cat#14-844) and in bulk (cat# 14-844-K). View All» Entrez Gene Number: U78577 View All» Purification Method: Immobilized metal affinity chromatography (IMAC) View All»