货号：14-853

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: hHR6A Conjugating Enzyme View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 100 µg View All» Product Overview: The family of UBC enzymes plays a central role in the ubiquitin pathway. Genetic studies with the S.cerevisiae Rad6 protein demonstrate a pleiotropic phenotype, including defects in DNA repair, proteolysis of N-end rule protein substrates, cellular proliferation, cell cycle progression and an inability to sporulate, which are all dependent on its ubiquitin-conjugating activity. Rad6 can ubiquitinylate histones in vitro, and ubiquitinylation of histone H2B in S.cerevisiae is Rad6 dependent. In mice and humans, two homologues of RAD6 have been identified - hHR6A (homologue of RAD6A) and hHR6B (homologue of RAD6B). UbcH2A is phosphorylated in vitro by CDK-1 and -2 on serine residue 120, which is conserved in all hHR6A homologs, leading to an increase in the ubiquitin-conjugating activity of this enzyme. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. View All» UniProt Summary: FUNCTION: SwissProt: P49459 # Catalyzes the covalent attachment of ubiquitin to other proteins. Required for postreplication repair of UV-damaged DNA.SIZE: 152 amino acids; 17315 Da SUBUNIT: Interacts with RAD18.SIMILARITY: SwissProt: P49459 ## Belongs to the ubiquitin-conjugating enzyme family. View All» Species: Human View All» Molecular Weight: 17 kDa View All» Brand Family: Upstate View All» Source: Recombinant human hHR6A Conjugating Enzyme expressed in E. coli. View All» Presentation: 100 μg of purified protein at a concentration of 1.0 mg/mL in 50 mM HEPES, pH 8.0, 50 mM NaCl, 10% Glycerol, 1 mM DTT. View All» Storage Conditions: As supplied, store at -80°C for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. After initial defrost, aliquot (for extended storage it is recommended that aliquots be no smaller then 10 μL) and store at -80°C. Snap-freezing in a dry ice/ethanol bath or liquid nitrogen is recommended. As supplied, the enzyme is stable on ice for several hours. View All» Gene Symbol:

• UBE2A

• HR6A

• RAD6A

• hHR6A

• UBC2

• HHR6A
  View All» Product Name: hHR6A Conjugating Enzyme View All» Alternate Names: Ubiquitin-conjugating enzyme E2 A View All» UniProt Number: P49459 View All» Entrez Gene Number:
  • NM_003336.2

  • NM_181762.1

  • NM_181777.1
    View All» Purity: >95% by SDS-PAGE View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://www.16ao.com/thread-146902.htm
    © Merck Millipore代理14-853 Ubiquitin conjugating enzyme hHR6A 6His;已停产，产品报价联系微信jinshanbio