货号：14-855

品牌：Merck Millipore

规格：1EA

目录价：￥4785.15

市场价格：￥4067.38

会员价格：￥3828.12

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Ubiquitin C-terminal hydrolase L1 (UCH-L1) View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 50 µg View All» Product Overview: Produced from human cDNA, expressed in E. coli. Ubiquitin C-terminal hydrolases (UCHs) are a family of cysteine hydrolases that catalyze the hydrolysis of amides, esters and thioesters of the C-terminus of ubiquitin. Mammalian neuronal cells abundantly express a deubiquitylating enzyme, ubiquitin carboxy-terminal hydrolase 1 (UCH-L1). Mutations in UCH-L1 are linked to Parkinson's disease as well as gracile axonal dystrophy (gad) in mice. In contrast to the universally expressed UCH-L3 isozyme, UCH-L1 is expressed exclusively in neurons and testis/ovary. It has been shown that UCH-L1 associates and co-localizes with monoubiquitin and elongates ubiquitin half-life and the suggestion is made that UCH-L1, with avidity and affinity for ubiquitin, ensures ubiquitin stability within neurons. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: UCHL1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is present in all neurons (Doran et al., 1983 [PubMed 6343558]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P09936 # Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.SIZE: 223 amino acids; 24824 Da SUBUNIT: Homodimer. Interacts with SNCA (By similarity). Interacts with COPS5.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Found in neuronal cell bodies and processes throughout the neocortex (at protein level). Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary.PTM: O-glycosylated (By similarity).DISEASE: SwissProt: P09936 # Oxidation of Met-1, Met-6, Met-12, Met-124 and Met-179 to methionine sulfoxide, and oxidation of Cys-220 to cysteine sulfonic acid have been observed in brains from Alzheimer disease (AD) and Parkinson disease (PD) patients. In AD, UCHL1 was found to be associated with neurofibrillary tangles.SIMILARITY: SwissProt: P09936 ## Belongs to the peptidase C12 family.MISCELLANEOUS: In contrast to UCHL3, does not hydrolyze a peptide bond at the C-terminal glycine of NEDD8. View All» Species: Human View All» Molecular Weight: 24.8 kDa View All» Brand Family: Upstate View All» Source: Recombinant human UCH-L1 expressed in E. coli View All» Storage Conditions: As supplied, store at -80°C for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. After initial defrost, aliquot (for extended storage it is recommended that aliquots be no smaller then 10 μL) and store at -80°C. Snap-freezing in a dry ice/ethanol bath or liquid nitrogen is recommended. As supplied, the enzyme is stable on ice for several hours. View All» Gene Symbol:

• UCHL1

• PARK5

• Uch-L1

• UCH-L1

• PGP9.5
  View All» Product Name: Ubiquitin C-terminal hydrolase L1 (UCH-L1) View All» UniProt Number: P09936 View All» Specific Activity: >1000 pmol/min/μg. Determined at 25°C with 1 μM ubiquitin-AMC as substrate and UCH-L1 at 20 pM (0.54 ng/mL). View All» Entrez Gene Number: NM_004181.3 View All»
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