货号：14-856

品牌：Merck Millipore

规格：50Ug

目录价：￥5025.00

市场价格：￥4271.25

会员价格：￥4020.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Ubiquitin C-terminal hydrolase L3 (UCH-L3) View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 50 µg View All» Product Overview: Produced from human cDNA, expressed in E. coli. Ubiquitin C-terminal hydrolases (UCHs) are a family of cysteine hydrolases that catalyze the hydrolysis of amides, esters and thioesters of the C-terminus of ubiquitin. UCH-L3 is a member of the lower molecular weight group of UCHs involved in the hydrolysis of small C-terminal derivatives of ubiquitin that form non-specifically during the process of protein ubiquitinylation. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» UniProt Summary: FUNCTION: SwissProt: P15374 # Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8.SIZE: 230 amino acids; 26183 Da SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, and testis.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.DISEASE: SwissProt: P15374 # A defect or alteration in the expression of enzymes catalyzing the removal of ubiquitin from ubiquitin-proteins conjugates may be a characteristic of neurodegenerative diseases such as Alzheimer disease, Parkinson disease, progressive supranuclear palsy, and Pick and Kuf disease. & Identified as a tumor-specific antigen in colon cancer.SIMILARITY: SwissProt: P15374 ## Belongs to the peptidase C12 family. View All» Species: Human View All» Molecular Weight: 26.2 kDa View All» Brand Family: Upstate View All» Source: Recombinant human UCH-L3 expressed in E.coli. View All» Storage Conditions: Store at -70°C for up to 12 months from date of receipt. As supplied, the enzyme is stable on ice for several hours. Activity is stable up to 6 freeze/thaw cycles (snap freezing in a dry/ice ethanol bath or liquid nitrogen). View All» Gene Symbol: UCHL3 View All» Product Name: Ubiquitin C-terminal hydrolase L3 (UCH-L3) View All» UniProt Number: P15374 View All» Specific Activity: >1000 pmol/min/μg. Determined at 25°C with 1 μM ubiquitin-AMC as substrate and UCH-L3 at 20 pM (0.58 ng/mL). View All» Entrez Gene Number: NM_006002.3 View All»