货号：14-858

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: SUMO Activating Enzyme View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 25 µg View All» Product Overview: SUMO conjugation to target proteins is mediated by a different, but analogous, pathway to ubiquitinylation. SUMO activating enzyme is a heterodimeric complex consisting of Aos1 and Uba2. Both subunits are well conserved from yeast to humans, with Aos2/SAE I being similar to the N-terminal half of the E1 enzyme for ubiquitin while Uba2/SAE II has similarity to the C-terminal half, and contains the active site cysteine residue required for formation of thioester bonds. However, Uba2 alone is not sufficient to catalyze SUMOylation. SUMO1 activating enzyme supports in vitro SUMOylation. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» UniProt Summary: FUNCTION: SwissProt: Q9UBT2 # The dimeric enzyme acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins and formation of a thioester with a conserved cysteine residue on SAE2.SIZE: 640 amino acids; 71224 Da SUBUNIT: Heterodimer of SAE1 and SAE2. The complex binds SUMO proteins via SAE2.SUBCELLULAR LOCATION: Nucleus.SIMILARITY: SwissProt: Q9UBT2 ## Belongs to the ubiquitin-activating E1 family. View All» Species: Human View All» Molecular Weight: 38 kDa and 90 kDa View All» Brand Family: Upstate View All» Source: Recombinant human Aos2 and SAE I co-expressed in an E.coli expression system View All» Storage Conditions: Maintain at -80°C for up to 12 months from date of receipt. Avoid multiple freeze/thaw cycles. After initial defrost, aliquot into individual tubes and refreeze at -80°C. View All» Gene Symbol:

• SAE1

• SUA1

• AOS1

• FLJ3091

• HSPC140

• Sua1

• UBLE1A
  View All» Product Name: SUMO Activating Enzyme View All» UniProt Number:
  • Q9UBE0

  • Q9UBT2
    View All» Entrez Gene Number: NM_005500.1 View All» Purification Method: Purified by GST affinity chromatography. The GST tag is subsequently removed by thrombin cleavage and the heterodimeric complex further purified by ion exchange chromatography (to remove GST/thrombin). View All»
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