货号：14-906

品牌：Merck Millipore

规格：

目录价：￥3898.00

市场价格：￥3313.30

会员价格：￥3118.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PI3K-C2α View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: N-terminal 6His-tagged recombinant human PI3K-C2α amino acids 299–end. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. View All» UniProt Summary: FUNCTION: Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2. May play a role in clathrin-coated endocytic vesicle formation and EGF signaling cascade. May be involved in mitosis and UV-induced damage response. May be a downstream effector in insulin signaling cascade.CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.COFACTOR: Calcium or magnesium. Manganese cannot be used. ENZYME REGULATION: Activated by insulin. Only slightly inhibited by wortmannin and LY294002. Activated by clathrin.Subunit structure: Part of a complex with ERBB2 and EGFR. Interacts with clathrin trimers. SUBCELLULAR LOCATION: Cell membrane. Golgi apparatus. Cytoplasmic vesicle › clathrin-coated vesicle. Nucleus. Cytoplasm. Associated with RNA-containing structures. TISSUE SPECIFICITY: Expressed in columnar and transitional epithelia, mononuclear cells, smooth muscle cells, and endothelial cells lining capillaries and small venules (at protein level). Ubiquitously expressed, with highest levels in heart, placenta and ovary, and lowest levels in the kidney.SIMILARITY: Belongs to the PI3/PI4-kinase family. Contains 1 C2 domain. Contains 1 PI3K/PI4K domain. Contains 1 PX (phox homology) domain. View All» Species: Human View All» Molecular Weight: 161kDa View All» Brand Family: Upstate View All» Source: Expressed by baculovirus in Sf21 insect cells View All» Protein Target: PI3K-C2α View All» Presentation: 10 μg of enzyme in 10.6 μl of 50 mM Tris/HCl, pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 0.2 mM PMSF, 1mM benzamidine, 0.1% 2-mercaptoethanol, 20 mM β-glycerophosphate, 0.25 mM Na₃VO₄, 10 mM NaF. Frozen solution. View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: PI3K/PI4K View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• PI3-kinase

• PIK3

• PI3K

• PTDINS-3-kinase

• PI3K C2a

• PI3-Kinase Class II
  View All» Product Name: PI3K-C2α View All» Quality Assurance: Routinely evaluated in the PIProfiler. View All» UniProt Number: O00443 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 250μg size as catalog # 14-906M - Call for pricing and availability. View All» Entrez Gene Number: NM_002645.2 View All» Purification Method: Immobilized metal affinity chromatography (IMAC) View All»
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