货号：14-907M

品牌：Merck Millipore

规格：1ea

目录价：￥42566.00

市场价格：￥36181.10

会员价格：￥34052.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PI3K-C2β View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: N-terminal 6His-tagged recombinant human PI3K-C2β, full length. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, andintracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs thatmediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of thisprotein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. View All» UniProt Summary: FUNCTION: Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.COFACTOR: Calcium, magnesium, or manganese. ENZYME REGULATION: Activated by GRB2. SUBUNIT STRUCTURE: Part of a complex with ERBB2 and EGFR. Part of a complex with phosphorylated EGFR and GRB2. Interacts with phosphorylated EGFR and PDGFR, maybe indirectly. Interacts with GRB2 and SHC1. SUBCELLULAR LOCATION: Microsome. Cell membrane. Cytoplasm › cytosol. Nucleus. Endoplasmic reticulum. Note: Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis. TISSUE SPECIFICITY: Expressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at protein level). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood, skeletal muscle and kidney. SEQUENCE SIMILARITIES: Belongs to the PI3/PI4-kinase family. Contains 1 C2 domain. Contains 1 PI3K/PI4K domain. Contains 1 PX (phox homology) domain. View All» Species: Human View All» Molecular Weight: 189kDa View All» Brand Family: Upstate View All» Source: Expressed by baculovirus in Sf21 insect cells View All» Protein Target: PI3KC2β View All» Presentation: 10μg of enzyme in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 0.2mM PMSF, 1mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution. View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: PI3K/PI4K View All» Gene Symbol:

• PI3-kinase

• PIK3

• PI3K

• PTDINS-3-kinase

• PI3K C2b

• PI3-Kinase Class II

• PIK3C2B
  View All» Product Name: PI3K-C2β View All» Quality Assurance: Routinely evaluated in the PIProfiler. View All» UniProt Number: O00750 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 10 μg size (cat#14-907) and in bulk (cat# 14-907-K). View All» Entrez Gene Number: NM_002646 View All» Purification Method: Ni²⁺/NTA-agarose View All»
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  © Merck Millipore代理14-907M PI3K-C2β Protein, 10 µg;PI3K-C2β 蛋白，10 µgstore at -80℃，产品报价联系微信jinshanbio