货号：14-908

品牌：Merck Millipore

规格：10Ug

目录价：￥14636.00

市场价格：￥12440.60

会员价格：￥11708.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PI4KIIIα View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: N-terminal FLAG-tagged, recombinant human PI4KIIIα full length. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. Two transcript variants encoding different isoforms have been described for this gene. View All» UniProt Summary: FUNCTION: Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.ENZYME REGULATION: This is a type II PtdIns-4-kinase activated by detergents such as triton and inhibited by adenosine.TISSUE SPECIFICITY: Expressed ubiquitously. Highest levels in placenta and brain. Little or no expression in lung, liver, pancreas, testis or leukocytes.SEQUENCE SIMILARITIES: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. Contains 1 PI3K/PI4K domain. View All» Species: Human View All» Molecular Weight: 233kDa View All» Brand Family: Upstate View All» Source: Expressed by baculovirus in Sf21 insect cells View All» Protein Target: PI4KIIIα View All» Presentation: 10μg of enzyme in 50mM Tris/HCl pH 7.4, 150mM NaCl, 150µg/ml FLAG^TM peptide, 270mM sucrose, 0.2mM PMSF, 1mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution. View All» Storage Conditions: 6 months at -70°C View All» Target Sub-Family: PI3K/PI4K View All» Gene Symbol:

• PIK4CA

• pi4K230

• PI4K-ALPHA

• PI4KA

• FLJ16556
  View All» Product Name: PI4KIIIα View All» Quality Assurance: Routinely evaluated in the PIProfiler. View All» UniProt Number: P42356 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 250μg size as catalog # 14-908M - Call for pricing and availability. View All» Entrez Gene Number: NM_058004 View All» Purification Method: FLAG™ agarose View All»
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