货号：14-912M

品牌：Merck Millipore

规格：1ea

目录价：￥47391.00

市场价格：￥40282.35

会员价格：￥37912.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: TGFBR-1, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Product Overview: N-terminal GST-tagged, recombinant, human TGFBR1 amino acids 200–end containing a T204D mutation, expressed by baculovirus in Sf21 insect cells. Purified using glutathione agarose. View All» Background Information: Transforming growth factor, beta receptor type I (TGF-beta receptor I) forms a heteromeric complex with TGF-beta receptor type II when bound to TGF-beta. This complex transduces the TGF-beta signal from the cell surface to the cytoplasm. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. TGF-beta receptor I is found in all tissues, but is most abundant in placenta and least abundant in brain and heart tissue. TGF-beta receptor I is phosphorylated at basal levels in the absence of ligand binding and is multiply phosphorylated, mainly in the GS region. Defects in TGF-beta receptor I are the cause of Loeys-Dietz syndrome type 1A (LDS1A), also known as Furlong syndrome or Loeys-Dietz aortic aneurysm syndrome (LDAS). View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Species: Human View All» Molecular Weight: 62 kDa View All» Brand Family: Upstate View All» Source: Expressed by baculovirus in Sf21 insect cells. View All» Protein Target: TGFBR1 View All» Presentation: 50mM Tris-HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. View All» Storage Conditions: Store -70°C. For maximum recovery of product, centrifuge original vial prior to removing the cap. Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70°C. View All» Target Sub-Family: TKL View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol: TGFBR1 View All» Product Name: TGFBR-1, active View All» Alternate Names:

• TGF-beta receptor type-1

• TGFR-1

• Transforming growth factor-beta receptor type I

• TGF-beta receptor type I

• TbetaR-I

• TGF-beta type I receptor

• Serine/threonine-protein kinase receptor R4

• SKR4

• Activin receptor-like kinase 5

• ALK-5
  View All» Quality Assurance: Routinely evaluated by phosphorylation of casein. View All» UniProt Number:
  • P36897

  • Q64729 (mouse)
    View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Packaging: Also available in 10 μg size (cat#14-912) and in bulk (cat# 14-912-K). View All» Entrez Gene Number: NM_004612 View All» Purification Method: Glutathione agarose affinity chromatography View All»
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