货号：14-916

品牌：Merck Millipore

规格：

目录价：￥3677.00

市场价格：￥3125.45

会员价格：￥2941.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PEK, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Product Overview: N-terminal, 6His-tagged, recombinant human PEK, amino acids 536-end. View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» UniProt Summary: FUNCTION: Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1 (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Ubiquitous. A high level expression is seen in secretory tissues. PTM: Autophosphorylated. N-glycosylated (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. Contains 1 protein kinase domain. View All» Species: Human View All» Molecular Weight: 71 kDa View All» Brand Family: Upstate View All» Source: Human PEK expressed by baculovirus in Sf21 insect cells View All» Presentation: 50 mM Tris-HCl, pH 7.5, 0.3 M NaCl, 0.1 mM EGTA, 0.03 % Brij-35, 270 mM sucrose, 0.1% 2-mercaptoethanol, 1mM benzamidine, 200 μM PMSF View All» Storage Conditions: 6 months at -70°C View All» Promotional Text: This enzyme is part of KinaseProfiler™, a custom inhibitor selectivity discovery service. View All» Gene Symbol:

• PERK

• WRS

• EIF2AK3

• DKFZp781H1925
  View All» Product Name: PEK, active View All» Quality Assurance: Routinely evaluated by phosphorylation of RSRSRSRSRSRSRSR. For Specific Activity Data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» UniProt Number: Q9NZJ5 View All» Packaging: Also available in 250 µg size - call for pricing and availability and reference catalog number 14-916M when ordering the 250 µg size. View All» Entrez Gene Number: 9415 View All» Purification Method: Immobilised metal affinity chromatography View All»
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